By Eric Guaguere, Pascal Prelaud, D.W. Scott, M. Craig
A pragmatic advisor to tom cat Dermatology
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Additional info for A Practical guide to Feline Dermatology
A vicious cycle of release of cytokines, chemokines and growth factors keeps the disease active. The biologics break the cycle by negating the inflammatory action of TNF-α, IL-12 and other factors. Chemokine release dendritic cell (DC) and T-cell activation and migration Human TNF receptor extracellular domain Fig. 1 Diagram of the structure of the biologics. Infliximab and adalimumab are similar to normal human immunoglobulins. Etanercept contains the extracellular TNF receptor domain fused to parts of the human immunoglobulin heavy chain.
The surrounding skin is protected with a bland preparation such as white soft paraffin, and the treated area is covered with tube gauze. The combination of this with a daily tar bath and ultraviolet B is called the Ingram regimen. Psoriasis clears within 3 weeks in most patients on this treatment. The ‘short contact regimen’, in which dithranol is applied for 30 min each day, is suitable for outpatients with stable plaque psoriasis. The dithranol is best washed off in a shower. 1% to 2%. 1%; Zorac gel), is effective for chronic plaque psoriasis.
The biologics break the cycle by negating the inflammatory action of TNF-α, IL-12 and other factors. Chemokine release dendritic cell (DC) and T-cell activation and migration Human TNF receptor extracellular domain Fig. 1 Diagram of the structure of the biologics. Infliximab and adalimumab are similar to normal human immunoglobulins. Etanercept contains the extracellular TNF receptor domain fused to parts of the human immunoglobulin heavy chain. g. TNF-α, IL-12, INF-γ, chemokines and growth factors Endothelial proliferation Trafficking DC to lymph node Priming of naive T-cell takes place in local lymph node Activation of DC and T-cells Skin homing T-cell Endothelial cells express ICAM-1 and other signals Influx of activated CD8+ T-cells Recruitment of polymorph neutrophils Psoriasis – Biologics twice weekly to once every 3 months.